The specific vulnerability of the gastrointestinal system to TD, in the absence of more common signs of wet and dry beriberi, may arise from direct exposure of this system to the gut microbiome and oral drugs, along with the continuous need to redistribute thiamine to other tissues
from 13 to 50% is excreted unchanged in the urine
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[1] [2] Other uses include treatment for cyanide poisoning, Leber's optic atrophy, and toxic amblyopia